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TRT is not recommended if you have: 21 Uncontrolled heart failure* A recent heart attack (within six months) Untreated high blood pressure Sleep apnea A history of prostate cancer Plans to start a family (TRT suppresses fertility) *”Patients with other cardiac issues, if well managed, may be treated for low testosterone but require close cardiac monitoring,” says Staheli

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By connecting mechanistic insights with clinical interventions, this review offers a comprehensive framework that bridges basic research and potential clinical practice